Orthotopic models of pediatric brain tumors in zebrafish
نویسندگان
چکیده
منابع مشابه
Pediatric Brain Tumors
Primitive neuroectodermal tumors (PNET) of the brain include medulloblastoma (MB) and central nervous system primitive neuroectodermal tumor (CNS PNET) subtypes, which share histological features yet differ at the genomic level and in clinical outcome. Delineation of the genetic anomalies between PNET subtypes is a current challenge for establishing effective targeted therapeutic strategies aga...
متن کاملBiomarkers of Pediatric Brain Tumors
UNLABELLED Background and Need for Novel Biomarkers: Brain tumors are the leading cause of death by solid tumors in children. Although improvements have been made in their radiological detection and treatment, our capacity to promptly diagnose pediatric brain tumors in their early stages remains limited. This contrasts several other cancers where serum biomarkers such as cancer antigen (CA) 19-...
متن کاملImmunotherapy for Pediatric Brain Tumors
Malignant brain tumors are the most common cause of solid cancer death in children. New targeted therapies are vital to improve treatment outcomes, but must be developed to enable trafficking across the blood brain barrier (BBB). Since activated T cells cross the BBB, cancer immunotherapy can be harnessed to unlock the cytotoxic potential of the immune system. However, standard of care treatmen...
متن کاملNeurocognitive Outcomes in Pediatric Brain Tumors Survivors
Neurocognitive disorders are a common long-term effect in brain tumor survivors. The rate of intelligence quotient (IQ) decline is associated with a several risk factors, including tumor location, younger age at time of treatment, treatment intensity, in particular use of radiotherapy and radiotherapy dose, as well as clinical variables such as hydrocephalus and presence of epilepsy. Demyeliniz...
متن کاملChromosome abnormalities in pediatric brain tumors.
Recurrent, site-specific chromosome translocations and other cytogenetic abnormalities are being described in ever-increasing numbers and types of human tumors. Primary brain tumors are the most common pediatric solid tumor and differ from those of adults in both histology and clinical behavior. We examined chromosomes from 21 primary pediatric brain neoplasms grown in short-term tissue culture...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2014
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2014.107